As a post-doctoral researcher in the Subramanian lab, I am working to understand the mechanisms of host-pathogen interaction. I specifically study the immune evasive strategies developed by pathogens to subvert the host immune system to establish disease focusing on the intracellular pathogens Mycobacterium tuberculosis and Salmonella typhimurium. We combine experimental and computational data to dissect the complex crosstalk between the host and the pathogen. I am presently developing a systems-based approach to identify critical mediators at the transcriptional level that may act as potential targets for development of host-directed therapies. I am also a recipient of the 2020 AAI Career Re-entry award. Besides research I love cooking and travelling.
Bachelor in Science (B.Sc), in Physiology (Honors); 2006-2009; Tripura University, India
Master in Science (M.Sc) in Physiology, 2009-2011; University of Calcutta, India
Doctorate of Philosophy in Physiology, 2012-2017; University of Calcutta
Molecular biology, Imaging, in vivo animal models and in vitro primary cell culture models
Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, Dey S, Sa G, Das T, Chattopadhyay S. Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways. J Nutr Biochem. 2013 Dec;24(12):2040-50. doi:10.1016/j.jnutbio.2013.07.005.
Choudhury S, Ghosh S, Gupta P, Mukherjee S, Chattoadhyay S. Inflammation induced ROS generation causes pancreatic cell death through modulation of Nrf2-NF-κB and SAPK/JNK pathway. Free Rad Research. 2015 Sep;49(11):1371-1383. org/10.3109/10715762.2015.1075016
Mukherjee S, Ghosh S, Das DK, Chakraborty P, Choudhury S, Gupta P, Adhikary A, Dey S, Chattopadhyay S. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection – synthesis, characterization and in vitro evaluation. J Nutr Biochem.2015 Nov;26(11):1283-97. doi:10.1016/j.jnutbio.2015.06.003.
Choudhury S, Ghosh S, Mukherjee S, Gupta G, Bhattacharya S, Adhikary A and Chattopadhyay S Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells. J Nutr Biochem.2016 Dec;38:25-40. doi:10.1016/j.jnutbio.2016.09.001
Choudhury S, Gupta G, Ghosh S, Mukherjee S, Chakraborty P and Chattopadhyay S. Arsenic induced dose-dependent modulation of NFκB/IL-6 axis in thymocytes triggers differential immune responses. Toxicology.2016 May 16;357-358:85-96. doi:10.1016/j.tox.2016.06.005.
Ghosh S, Mukherjee S, Choudhury S, Gupta P, Adhikary A, Baral R, Chattopadhyay S. Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of Fluoxetine. Cell Signal.2015 Jul;27(7):1398-412. doi:10.1016/j.cellsig.2015.03.013.
Gupta P, Choudhury S, Sain A, Chowdhury O, Ghosh S, Mukherjee S, Chattopadhyay S. Dietary pomegranate alleviates murine pancreatitis by modulating Nrf2-p21 interaction and directing apoptosis to survival switch. J Nutr Biochem, 2018 April;66:17-28. org/10.1016/j.jnutbio.2018.12.009
Ghosh S, Choudhury S, Mukherjee S, Gupta P, Chowdhury O, Baral R, Chattopadhyay S. Fluoxetine triggers selective apoptosis in inflammation-induced proliferating (Ki-67high) thymocytes. Immunol Cell Biol.2019 May;97(5):470-484. doi:10.1111/imcb.12227
Ghosh S,Choudhury S, Chowdhury O, Mukherjee S, Das A, Sain A, Gupta P, Adhikary A, Chattopadhyay S. Inflammation-induced behavioral changes is driven by alterations in Nrf2-dependent apoptosis and autophagy in mouse hippocampus: Role of fluoxetine. Cell Signal. 2020 Apr; 68:109521 org/10.1016/j.cellsig.2019.109521