Naeha Subramanian, PhD

Associate Professor

subramanian.isbscience.org/bio/naeha-subramanian-phd/

Naeha Subramanian is an Associate Professor at the Institute for Systems Biology and Affiliate Associate Professor in the Department of Immunology at the University of Washington. She received her PhD in Immunology from the National Institute of Immunology in New Delhi, India, and completed her postdoctoral training at the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). She is the recipient of the G.P. Talwar Medal for Best PhD Thesis (2009), NIAID Merit Award (2011), NIH Director’s Award (2012) and NIAID Performance Award (2014) in recognition of research excellence.

Naeha’s research interests lie in the molecular mechanisms of innate immunity and its role in host defense against pathogens and development of immune disease. The lab also works in the area of human immunology – especially systems-level studies of the immune response in patients with Lyme Disease. Her lab’s main focus is to investigate the function and regulation of a class of intracellular sensors called the NOD-like receptors (NLRs) in health, infectious disease, and complex immune-mediated disorders like cancer and autoimmunity.

PhD, Immunology, National Institute of Immunology, New Delhi

Immunology, Innate Immunity, Host-Pathogen Interactions

Subramanian, N., & Qadri, A. (2006). Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella. Nat Immunol, 7, 583–589. https://doi.org/10.1038/ni1336 Cite Download

Kastenmüller, W., Gasteiger, G., Subramanian, N., Sparwasser, T., Busch, D. H., Belkaid, Y., Drexler, I., & Germain, R. N. (2011). Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol, 187, 3186–3197. https://doi.org/10.4049/jimmunol.1101649 Cite Download

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., Romberg, N., Komarow, H., Aksentijevich, I., Kim, H. S., Ho, J., Cruse, G., Jung, M.-Y., Gilfillan, A. M., Metcalfe, D. D., … Milner, J. D. (2012). Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med, 366, 330–338. https://doi.org/10.1056/NEJMoa1102140 Cite Download

Kastenmüller, W., Torabi-Parizi, P., Subramanian, N., Lämmermann, T., & Germain, R. N. (2012). A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell, 150, 1235–1248. https://doi.org/10.1016/j.cell.2012.07.021 Cite Download

Lee, G.-S., Subramanian, N., Kim, A. I., Aksentijevich, I., Goldbach-Mansky, R., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012). The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 492, 123–127. https://doi.org/10.1038/nature11588 Cite Download

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013). The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell, 153, 348–361. https://doi.org/10.1016/j.cell.2013.02.054 Cite Download

Hutcheon, C., Paulvannan, D., & Subramanian, N. (2015). Cyoplasmic sensing in innate immunity. In Encyclopedia of Cell Biology: Vol. Vol.3 (p. Pages 710-726). https://www.elsevier.com/books/encyclopedia-of-cell-biology/bradshaw/978-0-12-394447-4 Cite Download

Subramanian, N., Torabi-Parizi, P., Gottschalk, R. A., Germain, R. N., & Dutta, B. (2015). Network representations of immune system complexity. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 7(1), 13–38. Cite Download

Rommereim, L. M., & Subramanian, N. (2015). AIMing 2 Curtail Cancer. Cell, 162, 18–20. https://doi.org/10.1016/j.cell.2015.06.041 Cite Download

Hampton, H., Hutcheon, C., & Subramanian, N. (2016). NAGging Hexokinase PEPs up NLRP3. Cell Host & Microbe, 20(2), 130–132. https://doi.org/10.1016/j.chom.2016.07.017 Cite Download

Idso, M. N., Akhade, A. S., Arrieta-Ortiz, M. L., Lai, B. T., Srinivas, V., Hopkins, J. P., Gomes, A. O., Subramanian, N., Baliga, N., & Heath, J. R. (2020). Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria. Chemical Science, 11(11), 3054–3067. https://doi.org/10.1039/C9SC04842A Cite Download Download

Su, Y., Chen, D., Yuan, D., Lausted, C., Choi, J., Dai, C. L., Voillet, V., Duvvuri, V. R., Scherler, K., Troisch, P., Baloni, P., Qin, G., Smith, B., Kornilov, S. A., Rostomily, C., Xu, A., Li, J., Dong, S., Rothchild, A., … Heath, J. R. (2020). Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19. Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037 Cite Download

Akhade, A. S., Atif, S. M., Lakshmi, B. S., Dikshit, N., Hughes, K. T., Qadri, A., & Subramanian, N. (2020). Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2002747117 Cite Download

Rommereim, L. M., Akhade, A. S., Dutta, B., Hutcheon, C., Lounsbury, N. W., Rostomily, C. C., Savan, R., Fraser, I. D. C., Germain, R. N., & Subramanian, N. (2020). A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses. Science Signaling, 13(661). https://doi.org/10.1126/scisignal.aba3244 Cite Download

Su, Y., Yuan, D., Chen, D. G., Wang, K., Choi, J., Dai, C. L., Hong, S., Zhang, R., Xie, J., Li, S., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Ng, R. H., Lee, I., Fallen, S., Kornilov, S. A., Baloni, P., … Heath, J. R. (2021). Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19. MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004 Cite Download

Doan, P., Nguyen, P., Murugesan, A., Subramanian, K., Konda Mani, S., Kalimuthu, V., Abraham, B. G., Stringer, B. W., Balamuthu, K., Yli-Harja, O., & Kandhavelu, M. (2021). Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth. Cancers, 13(15), 3773. https://doi.org/10.3390/cancers13153773 Cite Download

Rommereim, L., Akhade, A. S., Germain, R. N., Fraser, I. D. C., & Subramanian, N. (2021). Lentivirus-mediated Conditional Gene Expression. Bio-Protocol, 11(21), e4205. https://doi.org/10.21769/BioProtoc.4205 Cite

Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014 Cite Download

Kari, S., Subramanian, K., Altomonte, I. A., Murugesan, A., Yli-Harja, O., & Kandhavelu, M. (2022). Programmed cell death detection methods: a systematic review and a categorical comparison. Apoptosis: An International Journal on Programmed Cell Death. https://doi.org/10.1007/s10495-022-01735-y Cite Download

Duvvuri, V. R., Baumgartner, A., Molani, S., Hernandez, P. V., Yuan, D., Roper, R. T., Matos, W. F., Robinson, M., Su, Y., Subramanian, N., Goldman, J. D., Heath, J. R., & Hadlock, J. J. (2022). Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping. Health Data Science, 2022, 0002. https://doi.org/10.34133/hds.0002 Cite Download

Kuchina, A., Yang, J., Aldridge, B., Janes, K. A., Subramanian, N., Krogan, N. J., Bouhaddou, M., Einav, S., Papin, J., & Germain, R. N. (2022). How can systems approaches help us understand and treat infectious disease? Cell Systems, 13(12), 945–949. https://doi.org/10.1016/j.cels.2022.11.009 Cite

Akhade, A. S., Mosquera, G. V., Arrieta-Ortiz, M. L., Kaur, A., Peterson, E. J. R., Baliga, N. S., Hughes, K. T., & Subramanian, N. (2022). A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance. The Journal of Immunology, 208(1_Supplement), 51.05. https://doi.org/10.4049/jimmunol.208.Supp.51.05 Cite

Akhade, A. S., & Subramanian, N. (2023). Cytoplasmic Sensing in Innate Immunity. In R. A. Bradshaw, G. W. Hart, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology (Second Edition) (pp. 624–643). Academic Press. https://doi.org/10.1016/B978-0-12-821618-7.00012-2 Cite

Naeha Subramanian, PhD

at the Institute for Systems Biology

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