ISB researchers have found that a small, persistent increase in the expression of NOD1 could be responsible for higher cancer risks. The research team found that a slight 1.5-fold uptick in NOD1 expression can activate the protein and downstream signaling pathways in a manner similar to vast (30- to 200-fold) overexpression.
GeekWire published a story spotlighting ISB’s COVID-19 research. Reporter Lisa Stiffler spoke with ISB President Dr. Jim Heath about the breakneck pace ISB and all of our collaborative partners are working at to tease out COVID’s biological secrets to advance the understanding and treatment of the novel coronavirus.
While scientists have long studied bacterial infections, less attention has been paid to how the host immune response affects bacterial gene expression in the body. In a just-published paper in PNAS, ISB researchers detailed how the bacterium Salmonella conceals itself from the host immune system.
ISB Assistant Professor Dr. Naeha Subramanian presented at the virtual meeting, Cytokines 2020, on November 1-4. Talk are available on demand for the registrants until November 18.
Findings from the ISB-Swedish COVID-19 Immune Response Study suggest that treatments aimed at arresting the infection at the stage of moderate severity may be most effective. The team studied 139 patients and found that mild COVID-19 is very distinct from the moderate or severe forms of disease, which appear surprisingly similar.
Subramanian Lab Research Scientist Dr. Ajay Akhade receives AAI Trainee Abstract Award. His abstract was selected for an oral presentation. The American Association of Immunologists is an association of professionally trained scientists from all over the world dedicated to advancing the knowledge of immunology and its related disciplines.
The AAI Fellowship Program for Career Reentry provides support for immunologists to reenter the workforce after a lapse of research or research training due to medical leave or family circumstances.
Since national surveillance of Lyme Disease started in 1982, the number of cases reported annually has increased nearly 25-fold. Lyme Disease specialist Dr. Susan Marra recently produced a video, “Ending Lyme,” about the latest in Lyme research that features ISB Drs. Jim Heath, Lee Hood, Rob Moritz, Naeha Subramanian and Nathan Price.
Leah and Ajay receive AAI Trainee Abstract Awards. Their abstracts are selected for oral presentations at Immunology 2019
In honor of National Postdoc Appreciation Week in late September, ISB’s staff recently gathered to honor and celebrate all of our devoted and hardworking postdocs. The event included speeches from a number of faculty members. “Postdocs are the heart of ISB,” Dr. Nathan Price, professor and associate director, told the gathering.
Summer 2017 brought a fresh cohort of undergraduate students interested in exploring ISB’s research in the Summer Undergraduate Research Experience Program.
Few systems approach the complexity of our own immune system, which promotes a swift and powerful host defense by coordinating a dynamic, multiscale set of hierarchically organized molecular, cellular, and organismal components. This article in Genetic Engineering and Biotechnology News covered Dr. Subramanian’s presentation at the symposium, “Future of Health.”
PRESS RELEASE Total Funding Has Reached $6.1 Million ISB Researchers Have Discovered Potential Biomarkers and Successfully Reproduced the Borrelia Bacteria in the Lab SEATTLE – June 1, 2016 – Institute for Systems Biology (ISB) has received a transformational, multi-year pledge from the Steven & Alexandra Cohen Foundation to support the Wilke Cohen Lyme Disease Project. In addition to an initial $3.1 million in funding from Jeff and Liesl Wilke, Jeff…
Study Utilizes Systems Approaches to Develop Diagnostics and Deeper Understanding of Chronic Lyme PRESS RELEASE, SEATTLE, March 26, 2015 – Institute for Systems Biology (ISB) has received $2.13 million in transformational gifts from Jeff and Liesl Wilke; Jeff and MacKenzie Bezos; and the Bay Area Lyme Foundation to tackle chronic Lyme disease, a highly complex and often misdiagnosed disease that can be debilitating for those who do not respond to…