Publications

Akhade, A. S., & Subramanian, N. (2023). Cytoplasmic Sensing in Innate Immunity. In R. A. Bradshaw, G. W. Hart, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology (Second Edition) (pp. 624–643). Academic Press. https://doi.org/10.1016/B978-0-12-821618-7.00012-2 Cite

Akhade, A. S., Mosquera, G. V., Arrieta-Ortiz, M. L., Kaur, A., Peterson, E. J. R., Baliga, N. S., Hughes, K. T., & Subramanian, N. (2022). A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance. The Journal of Immunology, 208(1_Supplement), 51.05. https://doi.org/10.4049/jimmunol.208.Supp.51.05 Cite

Kuchina, A., Yang, J., Aldridge, B., Janes, K. A., Subramanian, N., Krogan, N. J., Bouhaddou, M., Einav, S., Papin, J., & Germain, R. N. (2022). How can systems approaches help us understand and treat infectious disease? Cell Systems, 13(12), 945–949. https://doi.org/10.1016/j.cels.2022.11.009 Cite

Duvvuri, V. R., Baumgartner, A., Molani, S., Hernandez, P. V., Yuan, D., Roper, R. T., Matos, W. F., Robinson, M., Su, Y., Subramanian, N., Goldman, J. D., Heath, J. R., & Hadlock, J. J. (2022). Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping. Health Data Science, 2022, 0002. https://doi.org/10.34133/hds.0002 Cite Download

Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014 Cite Download

Rommereim, L., Akhade, A. S., Germain, R. N., Fraser, I. D. C., & Subramanian, N. (2021). Lentivirus-mediated Conditional Gene Expression. Bio-Protocol, 11(21), e4205. https://doi.org/10.21769/BioProtoc.4205 Cite

Su, Y., Yuan, D., Chen, D. G., Wang, K., Choi, J., Dai, C. L., Hong, S., Zhang, R., Xie, J., Li, S., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Ng, R. H., Lee, I., Fallen, S., Kornilov, S. A., Baloni, P., … Heath, J. R. (2021). Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19. MedRxiv, 2021.03.19.21254004. https://doi.org/10.1101/2021.03.19.21254004 Cite Download

Rommereim, L. M., Akhade, A. S., Dutta, B., Hutcheon, C., Lounsbury, N. W., Rostomily, C. C., Savan, R., Fraser, I. D. C., Germain, R. N., & Subramanian, N. (2020). A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses. Science Signaling, 13(661). https://doi.org/10.1126/scisignal.aba3244 Cite Download

Akhade, A. S., Atif, S. M., Lakshmi, B. S., Dikshit, N., Hughes, K. T., Qadri, A., & Subramanian, N. (2020). Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2002747117 Cite Download

Su, Y., Chen, D., Yuan, D., Lausted, C., Choi, J., Dai, C. L., Voillet, V., Duvvuri, V. R., Scherler, K., Troisch, P., Baloni, P., Qin, G., Smith, B., Kornilov, S. A., Rostomily, C., Xu, A., Li, J., Dong, S., Rothchild, A., … Heath, J. R. (2020). Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19. Cell, S0092867420314446. https://doi.org/10.1016/j.cell.2020.10.037 Cite Download

Idso, M. N., Akhade, A. S., Arrieta-Ortiz, M. L., Lai, B. T., Srinivas, V., Hopkins, J. P., Gomes, A. O., Subramanian, N., Baliga, N., & Heath, J. R. (2020). Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria. Chemical Science, 11(11), 3054–3067. https://doi.org/10.1039/C9SC04842A Cite Download Download

Hampton, H., Hutcheon, C., & Subramanian, N. (2016). NAGging Hexokinase PEPs up NLRP3. Cell Host & Microbe, 20(2), 130–132. https://doi.org/10.1016/j.chom.2016.07.017 Cite Download

Rommereim, L. M., & Subramanian, N. (2015). AIMing 2 Curtail Cancer. Cell, 162, 18–20. https://doi.org/10.1016/j.cell.2015.06.041 Cite Download

Hutcheon, C., Paulvannan, D., & Subramanian, N. (2015). Cyoplasmic sensing in innate immunity. In Encyclopedia of Cell Biology: Vol. Vol.3 (p. Pages 710-726). https://www.elsevier.com/books/encyclopedia-of-cell-biology/bradshaw/978-0-12-394447-4 Cite Download

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013). The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell, 153, 348–361. https://doi.org/10.1016/j.cell.2013.02.054 Cite Download

Lee, G.-S., Subramanian, N., Kim, A. I., Aksentijevich, I., Goldbach-Mansky, R., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012). The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 492, 123–127. https://doi.org/10.1038/nature11588 Cite Download

Kastenmüller, W., Torabi-Parizi, P., Subramanian, N., Lämmermann, T., & Germain, R. N. (2012). A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell, 150, 1235–1248. https://doi.org/10.1016/j.cell.2012.07.021 Cite Download

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., Romberg, N., Komarow, H., Aksentijevich, I., Kim, H. S., Ho, J., Cruse, G., Jung, M.-Y., Gilfillan, A. M., Metcalfe, D. D., … Milner, J. D. (2012). Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med, 366, 330–338. https://doi.org/10.1056/NEJMoa1102140 Cite Download

Kastenmüller, W., Gasteiger, G., Subramanian, N., Sparwasser, T., Busch, D. H., Belkaid, Y., Drexler, I., & Germain, R. N. (2011). Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol, 187, 3186–3197. https://doi.org/10.4049/jimmunol.1101649 Cite Download

Subramanian, N., & Qadri, A. (2006). Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella. Nat Immunol, 7, 583–589. https://doi.org/10.1038/ni1336 Cite Download