Naeha Subramanian, PhD

Associate Professor

Naeha Subramanian is an Associate Professor at the Institute for Systems Biology and Affiliate Associate Professor in the Department of Immunology at the University of Washington. She received her PhD in Immunology from the National Institute of Immunology in New Delhi, India, and completed her postdoctoral training at the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). She is the recipient of the G.P. Talwar Medal for Best PhD Thesis (2009), NIAID Merit Award (2011), NIH Director’s Award (2012) and NIAID Performance Award (2014) in recognition of research excellence.

Naeha’s research interests lie in the molecular mechanisms of innate immunity and its role in host defense against pathogens and development of immune disease. The lab also works in the area of human immunology – especially systems-level studies of the immune response in patients with Lyme Disease. Her lab’s main focus is to investigate the function and regulation of a class of intracellular sensors called the NOD-like receptors (NLRs) in health, infectious disease, and complex immune-mediated disorders like cancer and autoimmunity.

PhD, Immunology, National Institute of Immunology, New Delhi

Immunology, Innate Immunity, Host-Pathogen Interactions

Subramanian, N., & Qadri, A. (2006). Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella. Nat Immunol, 7, 583–589. Cite Download
Kastenmüller, W., Gasteiger, G., Subramanian, N., Sparwasser, T., Busch, D. H., Belkaid, Y., Drexler, I., & Germain, R. N. (2011). Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol, 187, 3186–3197. Cite Download
Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., Romberg, N., Komarow, H., Aksentijevich, I., Kim, H. S., Ho, J., Cruse, G., Jung, M.-Y., Gilfillan, A. M., Metcalfe, D. D., … Milner, J. D. (2012). Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med, 366, 330–338. Cite Download
Kastenmüller, W., Torabi-Parizi, P., Subramanian, N., Lämmermann, T., & Germain, R. N. (2012). A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell, 150, 1235–1248. Cite Download
Lee, G.-S., Subramanian, N., Kim, A. I., Aksentijevich, I., Goldbach-Mansky, R., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012). The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 492, 123–127. Cite Download
Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013). The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell, 153, 348–361. Cite Download
Hutcheon, C., Paulvannan, D., & Subramanian, N. (2015). Cyoplasmic sensing in innate immunity. In Encyclopedia of Cell Biology: Vol. Vol.3 (p. Pages 710-726). Cite Download
Subramanian, N., Torabi-Parizi, P., Gottschalk, R. A., Germain, R. N., & Dutta, B. (2015). Network representations of immune system complexity. Wiley Interdisciplinary Reviews. Systems Biology and Medicine, 7(1), 13–38. Cite Download
Rommereim, L. M., & Subramanian, N. (2015). AIMing 2 Curtail Cancer. Cell, 162, 18–20. Cite Download
Hampton, H., Hutcheon, C., & Subramanian, N. (2016). NAGging Hexokinase PEPs up NLRP3. Cell Host & Microbe, 20(2), 130–132. Cite Download
Idso, M. N., Akhade, A. S., Arrieta-Ortiz, M. L., Lai, B. T., Srinivas, V., Hopkins, J. P., Gomes, A. O., Subramanian, N., Baliga, N., & Heath, J. R. (2020). Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria. Chemical Science, 11(11), 3054–3067. Cite Download Download
Su, Y., Chen, D., Yuan, D., Lausted, C., Choi, J., Dai, C. L., Voillet, V., Duvvuri, V. R., Scherler, K., Troisch, P., Baloni, P., Qin, G., Smith, B., Kornilov, S. A., Rostomily, C., Xu, A., Li, J., Dong, S., Rothchild, A., … Heath, J. R. (2020). Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19. Cell, S0092867420314446. Cite Download
Akhade, A. S., Atif, S. M., Lakshmi, B. S., Dikshit, N., Hughes, K. T., Qadri, A., & Subramanian, N. (2020). Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages. Proceedings of the National Academy of Sciences of the United States of America. Cite Download
Rommereim, L. M., Akhade, A. S., Dutta, B., Hutcheon, C., Lounsbury, N. W., Rostomily, C. C., Savan, R., Fraser, I. D. C., Germain, R. N., & Subramanian, N. (2020). A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses. Science Signaling, 13(661). Cite Download
Su, Y., Yuan, D., Chen, D. G., Wang, K., Choi, J., Dai, C. L., Hong, S., Zhang, R., Xie, J., Li, S., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Ng, R. H., Lee, I., Fallen, S., Kornilov, S. A., Baloni, P., … Heath, J. R. (2021). Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19. MedRxiv, 2021.03.19.21254004. Cite Download
Doan, P., Nguyen, P., Murugesan, A., Subramanian, K., Konda Mani, S., Kalimuthu, V., Abraham, B. G., Stringer, B. W., Balamuthu, K., Yli-Harja, O., & Kandhavelu, M. (2021). Targeting Orphan G Protein-Coupled Receptor 17 with T0 Ligand Impairs Glioblastoma Growth. Cancers, 13(15), 3773. Cite Download
Rommereim, L., Akhade, A. S., Germain, R. N., Fraser, I. D. C., & Subramanian, N. (2021). Lentivirus-mediated Conditional Gene Expression. Bio-Protocol, 11(21), e4205. Cite
Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). Cite Download
Kari, S., Subramanian, K., Altomonte, I. A., Murugesan, A., Yli-Harja, O., & Kandhavelu, M. (2022). Programmed cell death detection methods: a systematic review and a categorical comparison. Apoptosis: An International Journal on Programmed Cell Death. Cite Download
Duvvuri, V. R., Baumgartner, A., Molani, S., Hernandez, P. V., Yuan, D., Roper, R. T., Matos, W. F., Robinson, M., Su, Y., Subramanian, N., Goldman, J. D., Heath, J. R., & Hadlock, J. J. (2022). Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping. Health Data Science, 2022, 0002. Cite Download
Kuchina, A., Yang, J., Aldridge, B., Janes, K. A., Subramanian, N., Krogan, N. J., Bouhaddou, M., Einav, S., Papin, J., & Germain, R. N. (2022). How can systems approaches help us understand and treat infectious disease? Cell Systems, 13(12), 945–949. Cite
Akhade, A. S., Mosquera, G. V., Arrieta-Ortiz, M. L., Kaur, A., Peterson, E. J. R., Baliga, N. S., Hughes, K. T., & Subramanian, N. (2022). A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance. The Journal of Immunology, 208(1_Supplement), 51.05. Cite
Akhade, A. S., & Subramanian, N. (2023). Cytoplasmic Sensing in Innate Immunity. In R. A. Bradshaw, G. W. Hart, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology (Second Edition) (pp. 624–643). Academic Press. Cite