News

Drs. Naeha Subramanian, Leah Rommereim Gilmore, and Ajay Suresh Akhade

Small, Persistent Increase in the Expression of NOD1 May Promote Cancer Risk

ISB researchers have found that a small, persistent increase in the expression of NOD1 could be responsible for higher cancer risks. The research team found that a slight 1.5-fold uptick in NOD1 expression can activate the protein and downstream signaling pathways in a manner similar to vast (30- to 200-fold) overexpression.

Subramanian and Akhade

How Salmonella Co-Opts the Host Immune System to Conceal Itself

While scientists have long studied bacterial infections, less attention has been paid to how the host immune response affects bacterial gene expression in the body. In a just-published paper in PNAS, ISB researchers detailed how the bacterium Salmonella conceals itself from the host immune system.

Corresponding author and ISB President Dr. Jim Heath and lead author Dr. Yapeng Su.

COVID-19 Immune Response Study Could Lead to More Effective Treatments

Findings from the ISB-Swedish COVID-19 Immune Response Study suggest that treatments aimed at arresting the infection at the stage of moderate severity may be most effective. The team studied 139 patients and found that mild COVID-19 is very distinct from the moderate or severe forms of disease, which appear surprisingly similar.